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A fast, accurate, and modularized dimensionality reduction approach based on diffusion harmonics and graph layouts. Escalates to millions of samples on a personal laptop. Adds high-dimensional big data intrinsic structure to your clustering and data visualization workflow.

Home Page: https://dbmap.readthedocs.io/en/latest/

License: GNU General Public License v2.0

Python 100.00%
dimensionality-reduction single-cell visualization high-dimensional diffusion-process machine-learning graph-layout umap nearest-neighbors denoising

dbmap's Introduction

Stars Twitter

Hi! I'm Davi

I develop tools to understand and interpret high-dimensional data, with a focus on single-cell omics.

  • I developed TopOMetry, a comprehensive framework for high-dimensional data analysis. TopOMetry learns similarity graphs, estimates the dimensionality of the data, obtains latent dimensions using topological operators, clusters samples and layouts topological graphs into two-dimensional visualizations. TopOMetry learns and evaluates dozens of possible visualizations so that users do not have to stick with any pre-determined model (e.g. t-SNE or UMAP). It was designed to be compatible with a scikit-learn centered workflow, as most classes and functions can be pipelined. TopOMetry manuscript is freely available at BioRxiv.

  • I'm currently a postdoc at Ana Domingos' lab at the University of Oxford. We are working on generating and analyzing single-cell datasets from a variety of tissues relevant to obesity and metabolism to build updated comprehensive neuroanatomical maps with cellular resolution. These will serve as a foundation for new studies investigating cellular-specific therapeutic targets for obesity and its comorbidities.

I'm always open to interesting conversations and enjoy getting involved in many projects. Feel free to reach me by email.

I tweet about medicine, neuroscience, computational biology, machine learning, and sometimes about my personal life.

dbmap's People

Contributors

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dbmap's Issues

dbmap in reticulate

Hi!

Is it possible to use this through reticulate?

Fast approximate nearest neighbour functions well. However, fast adaptive multiscaled diffusion maps, the last part of the code does not work:

ind, dist, grad, graph = diff.ind_dist_grad(data)

which in R i used:

diff$ind_dist_grad(data).

However, for this I receive this error:

Error in py_call_impl(callable, dots$args, dots$keywords) :
RuntimeError: 2021-01-04 17:55:21 spacefactory.h:50 (CreateSpace) It looks like the space cosine is not defined for the distance type : FLOAT

Detailed traceback:
File "/Users/knight05/Library/r-miniconda/envs/r-reticulate/lib/python3.6/site-packages/dbmap/diffusion.py", line 406, in ind_dist_grad
).fit(mms)
File "/Users/knight05/Library/r-miniconda/envs/r-reticulate/lib/python3.6/site-packages/dbmap/ann.py", line 145, in fit
data_type=nmslib.DataType.DENSE_VECTOR)

Are you able to indicate why this could be happening?

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