cmu-safari / genome-on-diet Goto Github PK

Very interesting work, and some nice results in terms of performance and sensitivity! However, the false positive rate is pretty startling--I suspect it is unacceptably high for many applications.

In section 3.6.3 I noticed this concept of "rescue mapping" when there is no hit above the user-provided threshold. I was curious: do you see any enrichment for false positives among these rescued reads? You mention that it improves sensitivity, but I am curious what the cost is.