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The Medullo-Model To Subtypes (MM2S) classifier stratifies single MB gene expression profiles without reference samples or replicates. Our pathway-centric approach facilitates subtype predictions of patient samples, and model systems including cell lines and mouse models.  
The manuscript link is: 
http://www.sciencedirect.com/science/article/pii/S0888754315000774 

The MM2S and MM2Sdata packages are available on CRAN:

** To install the MM2S and the MM2Sdata packages, from within an R terminal, please type:

install.packages("MM2S", repos="http://cran.r-project.org")
library(MM2S)
install.packages("MM2Sdata", repos="http://cran.r-project.org")
library(MM2Sdata)

** Load the libraries in R:
library(MM2S)
library(MM2Sdata)

** To install dependencies of the package, please run the following in R:
install.packages("BiocManager", repos="http://cran.r-project.org")
rr <- BiocManager::install(pkgs=c("GSVA", "kknn", "lattice", "pheatmap"), dependencies=TRUE, type="source", destdir=".")