A High-Throughput Approach Integrating Gene Expression Signatures and Clinical Data to Repurpose Drugs.

This R package contains functions to integrate gene expression and clinical data to identify and validate drug repurposing candidates.

To install the latest development version directly from GitHub, use:

#Install required packages
devtools::install_github("pwatrick/DrugRepurposingToolKit")

• Documentation can be found on the package website.
• Example for identifying drug repurposing candidates using gene expression signature matching can be found at vignette
• Example for performing query on the All of Us Research Program workbench, data processing, and statistical testing vignette.

Apache License 2.0

This package was developed in RStudio.

This package is ready for use.

Wu, P., Feng, Q., Kerchberger, V.E. et al. Integrating gene expression and clinical data to identify drug repurposing candidates for hyperlipidemia and hypertension. Nat Commun 13, 46 (2022). https://doi.org/10.1038/s41467-021-27751-1