Copyright (C) 2014 Jianxin Wang([email protected]),Cheng Yan([email protected])

This program is free software; you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation; either version 3 of the License, or (at your option) any later version.

This program is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. See the GNU General Public License for more details.

You should have received a copy of the GNU General Public License along with this program; if not, see http://www.gnu.org/licenses/.

Jianxin Wang([email protected]),Cheng Yan([email protected]) School of Information Science and Engineering Central South University ChangSha CHINA, 410083

BRWMDI is one novel computational method, which utilizes bi-random walk algorithm in diease and microbe networks to identify potential microbe-disease interactions.

1.DATA.

1. Disease_Number.xlsx store disease ids and names;

2. Microbe_Number.xlsx store microbe ids and names;

3. Disease-Microbe_Number.xlsx store the known microbe-disease interactions;

2.BRWMDI_5CV.

1. knowndiseasemicrobeinteraction.txt store the known microbe-disease interactions;

2. SymtomBased.mat store the symtom-based similarity of diseases;

3. main.m : main function;

4. BRWMDI5cv.m: function of 5-fold cross validation of BRWMDI;

5. BRWMDI.m: function of BRWMDI;

6. positiontooverallauc.m: function of calculating the AUC value;

7. SNF.m: function of similarity network fusion;

3.BRWMDI_LOOCV.

1. knowndiseasemicrobeinteraction.txt store the known microbe-disease interactions;

2. SymtomBased.mat store the symtom-based similarity of diseases;

3. main.m : main function;

4. BRWMDI_LOOCV.m: function of LOOCV of BRWMDI;

5. BRWMDI.m: function of BRWMDI;

6. positiontooverallauc.m: function of calculating the AUC value;

7. SNF.m: function of similarity network fusion;

All files of Data and Code should be stored in the same folder to run BRWMDI.