question: how to test two region sets for differential enrichment with buildRestrictedUniverse? about lola HOT 2 OPEN

# get the example data:
dbPath = system.file("extdata", "hg19", package="LOLA")
regionDB = loadRegionDB(dbLocation=dbPath)
data("sample_universe", package="LOLA")
data("sample_input", package="LOLA")
getRegionSet(regionDB, collections="ucsc_example", filenames="vistaEnhancers.bed")
getRegionSet(dbPath, collections="ucsc_example", filenames="vistaEnhancers.bed")
getRegionFile(dbPath, collections="ucsc_example", filenames="vistaEnhancers.bed")

# convert userSets to GRangesList
userSets = as(userSets, "GRangesList")

# redefine universe for enabling differential enrichment calculations between two test sets stored in userSets
universeRedefined = buildRestrictedUniverse(userSets)

# redefine userSets for a more appropriate statistical enrichment comparison
userSetsRedefined = redefineUserSets(userSets, universeRedefined )

# calculate enrichments with LOLA
resRedefined = runLOLA(userSetsRedefined, universeRedefined, regionDB, cores=1)

|userSet | dbSet|collection   |   pValueLog| oddsRatio| support| rnkPV| rnkOR| rnkSup| maxRnk| meanRnk|    b|    c|    d|description                      |cellType |tissue |antibody |treatment |dataSource |filename                    |    qValue|  size|
|:-------|-----:|:------------|-----------:|---------:|-------:|-----:|-----:|------:|------:|-------:|----:|----:|----:|:--------------------------------|:--------|:------|:--------|:---------|:----------|:---------------------------|---------:|-----:|
|setA    |     2|ucsc_example | 100.1529890| 3.2929780|    1062|     1|     3|      2|      3|    2.00|  579| 2510| 4507|ucsc_example                     |NA       |NA     |NA       |NA        |NA         |laminB1Lads.bed             | 0.0000000|  1302|
|setB    |     1|ucsc_example |  64.4426074| 6.5896984|    5766|     1|     1|      1|      1|    1.00| 2516|   97|  279|CpG islands from UCSC annotation |NA       |NA     |NA       |NA        |NA         |cpgIslandExt.bed            | 0.0000000| 28691|
|setA    |     4|ucsc_example |  19.0468632| 3.7602194|     151|     2|     1|      3|      3|    2.00|   59| 3421| 5027|ucsc_example                     |NA       |NA     |NA       |NA        |NA         |vistaEnhancers.bed          | 0.0000000|  1339|
|setA    |     5|ucsc_example |  19.0468632| 3.7602194|     151|     2|     1|      3|      3|    2.00|   59| 3421| 5027|ucsc_example                     |NA       |NA     |NA       |NA        |NA         |vistaEnhancers_colNames.bed | 0.0000000|  1340|
|setA    |     3|ucsc_example |   1.1644597| 2.8515119|       8|     4|     4|      5|      5|    4.33|    4| 3564| 5082|ucsc_example                     |NA       |NA     |NA       |NA        |NA         |numtSAssembled.bed          | 0.1369526|    78|
|setB    |     3|ucsc_example |   0.0012998| 0.2378840|       4|     2|     5|      5|      5|    4.00|    8| 5859| 2787|ucsc_example                     |NA       |NA     |NA       |NA        |NA         |numtSAssembled.bed          | 1.0000000|    78|
|setB    |     2|ucsc_example |   0.0000000| 0.4720576|     880|     3|     2|      2|      3|    2.33|  761| 4983| 2034|ucsc_example                     |NA       |NA     |NA       |NA        |NA         |laminB1Lads.bed             | 1.0000000|  1302|
|setB    |     4|ucsc_example |   0.0000000| 0.2836386|      80|     3|     3|      3|      3|    3.00|  130| 5783| 2665|ucsc_example                     |NA       |NA     |NA       |NA        |NA         |vistaEnhancers.bed          | 1.0000000|  1339|
|setB    |     5|ucsc_example |   0.0000000| 0.2836386|      80|     3|     3|      3|      3|    3.00|  130| 5783| 2665|ucsc_example                     |NA       |NA     |NA       |NA        |NA         |vistaEnhancers_colNames.bed | 1.0000000|  1340|
|setA    |     1|ucsc_example |   0.0000000| 0.1769031|    3276|     5|     5|      1|      5|    3.67| 5006|  296|   80|CpG islands from UCSC annotation |NA       |NA     |NA       |NA        |NA         |cpgIslandExt.bed            | 1.0000000| 28691|