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Viktorian Miok

Comprehensive molecular characterisation of HPV-induced transformation by longitudinal statistical modelling

Clone this thesis into a local folder using:

clone https://github.com/viktormok/PhD-thesis.git

To compile the thesis, change to the Thesis folder and use latexmk:

cd Thesis
latexmk -pdf thesis.tex

The pdf version of this thesis can be accessed here.

The work presented in this thesis has been done by me in collaboration with the persons listed in each section. When using to information of this thesis, please cite the associated papers:

Chapter 1: Introduction

Background, data generation and statistical analysis.

Chapter 2: tigaR: integrative significance analysis of temporal differential gene expression induced by genomic abnormalities

Miok, V., Wilting, S. M., van de Wiel, M. A., Jaspers, A., van Noort, P. I., Brakenhoff, R. H., Snijders, P. J. F., Steenbergen, R. D. M. and van Wieringen, W. N. tigaR: integrative significance analysis of temporal differential gene expression induced by genomic abnormalities, BMC Bioinformatics, (2014), 15: 327.

Chapter 3: Ridge estimation of the VAR(1) model and its time series chain graph from multivariate time-course omics data

Miok, V., Wilting, S. M. and van Wieringen, W. N. Ridge estimation of the VAR(1) model and its time series chain graph from multivariate time-course omics data, Biometrical Journal,(2017), 59(1), 172-191

Chapter 4: Ridge estimation of network models from time-course omics data

Miok, V., Wilting, S.M., van Wieringen, W.N. Ridge estimation of network models from time‐course omics data, Biometrical Journal, (2019), 61(2), 391-405.

Chapter 5: Comprehensive molecular profiling of HPV-induced transformation over time

Babion, I., Miok, V., Jaspers, A., Huseinovic, A., Steenbergen, R.D., van Wieringen, W.N., Wilting, S.M., Identification of Deregulated Pathways, Key Regulators, and Novel miRNA-mRNA Interactions in HPV-Mediated Transformation, Cancers, (2020), 12(3), 700.

Chapter 6: Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence

Wilting, S.M., Miok, V., Jaspers, A., Boon, D., Sorgard, H., Lando, M., Snoek, B.C., van Wieringen, W.N., Meijer, C.J., Lyng, H. and Snijders, P.J. Aberrant methylation-mediated silencing of microRNAs contributes to HPV-induced anchorage independence, Oncotarget, (2016), 7(28), 43805-43819

Chapter 7: Conclusion

Discussion and concluding remarks.

The figures in the introduction are my own work. When using or adapting them, please cite this thesis as follows:

Viktorian, M. (2019). Comprehensive molecular characterisation of HPV-induced transformation by longitudinal statistical modelling

PhD-thesis is distributed under the GPL-3.0 License. Please read the license before using PhD-thesis, which it is distributed in the LICENSE file.