Gene lists related to cancer immunotherapy

Last updated: July 21st, 2018

Sources:

• Frequent HLA class I alterations in human prostate cancer: molecular mechanisms and clinical relevance:
  • LMP2/7
  • peptide transporters TAP1/2
  • chaperones calreticulin, calnexin, ERP57, and tapasin
  • IFR-1 and NLRC5
• Expression of Antigen Processing and Presenting Molecules in Brain Metastasis of Breast Cancer
  • "β2-microgloblin, transporter associated with antigen processing (TAP) 1, TAP2 and calnexin are down-regulated in brain lesions compared with unpaired breast lesions"
• NLRC5/MHC class I transactivator is a target for immune evasion in cancer
• TAPBPR: a new player in the MHC class I presentation pathway

Last updated: July 21st, 2018

Sources:

• Interferon Receptor Signaling Pathways Regulating PD-L1 and PD-L2 Expression
  • "JAK1/JAK2-STAT1/STAT2/STAT3-IRF1 axis primarily regulates PD-L1 expression, with IRF1 binding to its promoter"
  • "PD-L2 responded equally to interferon beta and gamma and is regulated through both IRF1 and STAT3, which bind to the PD-L2 promoter"
  • "the suppressor of cytokine signaling protein family (SOCS; mostly SOCS1 and SOCS3) are involved in negative feedback regulation of cytokines that signal mainly through JAK2 binding, thereby modulating the activity of both STAT1 and STAT3"
• Mutations Associated with Acquired Resistance to PD-1 Blockade in Melanoma
  • "resistance-associated loss-of-function mutations in the genes encoding interferon-receptor–associated Janus kinase 1 (JAK1) or Janus kinase 2 (JAK2), concurrent with deletion of the wild-type allele"
• SOCS, inflammation, and cancer
  • "Abnormal expression of SOCS1 and SOCS3 in cancer cells has been reported in human carcinoma associated with dysregulation of signals from cytokine receptors"

Last updated: July 21st, 2018

Cancer genes and recurrent mutations extract from Comprehensive Characterization of Cancer Driver Genes and Mutations.

Genes extracted from Table S1, mutations extracted from Table S4.

Both datasets were annotated with Ensembl IDs using Ensembl release 92.