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PYCIRCOS COMPARATIVE SPECIES

  • Gene Ontology (GO_Slim)の共通性をcircos plotで可視化できないかと考えて作成しました

 

Prepared Data

  1. chromosome size

 

  1. HN-score (human and mouse)

    1. human

      • https://doi.org/10.6084/m9.figshare.23944935.v2
      • figshareにアップロードされているHN-scoreのデータをダウンロード
      • 使用されているgene nameに変更があることが判明したのでEnsembl gene IDに変換
      • g:profilerにアクセス
      • Ensembl genes 110のバージョンを使用
      • 重複してヒットした場合は遺伝子シンボルが同じIDを選択
      • すでに「Previous name」になっている場合はHGNCにアクセスし、再度手作業でIDを取得

      2023/11/05

      • 遺伝子の抽出の条件を変更したので再度同じ作業を実行
      • 重複してヒットした場合は遺伝子シンボルが同じIDを選択
      • HGNC accessed 2023/11/05
      • g:profiler accessed 2023/11/05

      2023/11/13

      • ファイルを間違って消してしまい、更にgitで追跡していなかったので再度同じ作業(g:convert)を実行
      • 重複してヒットした場合は遺伝子シンボルが同じIDを選択
      • HGNC accessed 2023/11/13
      • g:profiler accessed 2023/11/13

      Gene Convert (previous gene name -> current gene name) (2023/11/13)

       1. CDRT1: FBXW10B <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:14379>
       2. C7ORF61: SPACDR <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:22135>
       3. DDX58: RIGI <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:19102>
       4. C16ORF71: DNAAF8 <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:25081>
       5. GPR1: CMKLR2 <https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:4463>
      
    2. mouse

      • https://doi.org/10.6084/m9.figshare.23945073.v2
      • figshareにアップロードされているHN-scoreのデータをダウンロード
      • 使用されているgene nameに変更があることが判明したのでEnsembl gene IDに変換
      • g:profilerにアクセス
      • Ensembl genes 110のバージョンを使用 (AFFY_MOGENE_2_1_ST_V1)
      • 重複してヒットした場合は遺伝子シンボルが同じIDを選択
      • ない場合はMGIでも変換して検索
      • figshareのデータを更新

      Gene Convert (previous gene name -> current gene name) (2023/11/24 accessed) (MGI accessed 2023/11/24)

       1. GM21738: [対応するEnsembl gene IDなし]
       2. GM38100: Becn2 <https://www.informatics.jax.org/marker/MGI:2684950> 
       3. FAM71D: Garin2 <https://www.informatics.jax.org/marker/MGI:1918147>
       4. GM5741: Gng14 <https://www.informatics.jax.org/marker/MGI:3645690>
       5. AF366264: Semp2l2a <https://www.informatics.jax.org/marker/MGI:2667157>
       6. GM10720: ENSMUSG00000074564 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000074564>
       7. GM10800: ENSMUSG00000075014 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000075014>
       8. GM10801: ENSMUSG00000075015 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000075015>
       9. 1700007K13RIK: Pierce1 <https://www.informatics.jax.org/marker/MGI:1916577>
       10. Snapc1l: ENSMUSG00000114046 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000114046>
       11. GM10718: ENSMUSG00000095186 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000095186>
       12. GM11032: ENSMUSG00000079010 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000079010>
       13. GM43518: ENSMUSG00000105875 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000105875>
       14. A730071L15RIK: ENSMUSG00000096923 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000096923>
       15. 4930558C23RIK: Ctxnd2 <https://www.informatics.jax.org/marker/MGI:1914904>
       16. GM10799: ENSMUSG00000075006 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000075006>
       17. 4632433K11RIK: ENSMUSG00000116184 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000116184>
       18. GM10203: ENSMUSG00000067292 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000067292>
       19. G530012D18RIK: ENSMUSG00000094127 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000094127>
       20. GM50364: ENSMUSG00000117732 (MGIでは変換が出てきた) <https://useast.ensembl.org/Mus_musculus/Gene/Idhistory?g=ENSMUSG00000117732>
      

 

  1. Gene Ontology (GOSlim)

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