This repo is the official implementation of Towards Generic Semi-Supervised Framework for Volumetric Medical Image Segmentation which is accepted at NeurIPS-2023.

🚀 The significance of this work lies in its ability to encourage semi-supervised medical image segmentation methods to address more complex real-world application scenarios, rather than just developing frameworks in ideal experimental environments. Furthermore, we have consolidated all four settings within this single codebase, enabling the execution of any task using a single bash file by merely adjusting the arguments.

Online Presentation Video is available for brief introduction.

First, create a new environment and install the requirements:

conda create -n genericssl python=3.8
conda activate genericssl
cd GenericSSL/
pip install -r requirements.txt

[📌IMPORTANT] Then, before running the code, set the PYTHONPATH to pwd:

export PYTHONPATH=$(pwd)/code:$PYTHONPATH

First, download the datasets and put them under the Datasets folder:

• LASeg dataset for SSL: download the preprocessed data from https://github.com/yulequan/UA-MT/tree/master/data.

• Synapse dataset for IBSSL: The MR imaging scans are available at https://www.synapse.org/#!Synapse:syn3193805/wiki/. Please sign up and download the dataset. 🚀🚀🚀 Or download the preprocessed data via this link.

• MMWHS dataset for UDA: download according to https://github.com/cchen-cc/SIFA#readme. 🚀🚀🚀 Or download the preprocessed data via this link.

• M&Ms dataset for SemiDG: download from https://www.ub.edu/mnms/, after unzipping the dataset, you will get an OpenDataset folder, then you need to run the python coda/data/split_MNMS_data.py to spilt and get MNMs folder. 🚀🚀🚀 Or download the preprocessed data via this link.

The file structure should be:

.
├── Datasets
│   ├── LASeg
│   │   ├── 2018LA_Seg_Training Set
│   │   │   ├── 0RZDK210BSMWAA6467LU
│   │   │   │   ├── mri_norm2.h5
│   │   │   ├── 1D7CUD1955YZPGK8XHJX
│   │   │   └── ...
│   │   ├── test.list
│   │   └── train.list
│   ├── MMWHS
│   │   ├── CT
│   │   │   ├── imagesTr
│   │   │   │   ├── ct_train_1001_image.nii.gz
│   │   │   │   └── ...
│   │   │   └── labelsTr
│   │   │   │   ├── ct_train_1001_label.nii.gz
│   │   │   │   └── ...
│   │   └── MR
│   │       ├── imagesTr
│   │       └── labelsTr
│   ├── MNMs
│   │   └── Labeled
│   │       ├── VendorA
│   │       │   ├── A0S9V9
│   │       │   │   ├── A0S9V9_sa.nii.gz
│   │       │   │   ├── A0S9V9_sa_gt.nii.gz
│   │       │   ├── A1D9Z7
│   │       │   └── ...
│   │       ├── VendorB
│   │       ├── VendorC
│   │       └── VendorD
│   ├── OpenDataset
│   │   ├── Testing
│   │   ├── Training
│   │   ├── Validation
│   │   └── mnms_dataset_info.xls
│   └── Synapse
│       ├── imagesTr
│       │   ├──img0001.nii.gz
│       │   └── ...
│       └── labelsTr
│           ├──label0001.nii.gz
│           └── ...

Run python ./code/data/preprocess_la.py to:

• convert .h5 files to .npy.
• generate the labeled/unlabeled splits

Run python ./code/data/preprocess_synapse.py to

• resize the images and convert to .npy for faster loading;
• generate the train/test splits (use labeled data for validation);
• generate the labeled/unlabeled splits.

Run python ./code/data/preprocess_mmwhs.py to:

• reorient to the same orientation, RAI;
• convert to continuous labels;
• crop centering at the heart region;
• for each 3D cropped image top 2/% of its intensity histogram was cut off for alleviating artifacts;
• resize and convert to .npy;
• generate the train/validation/test splits.

Run python ./code/data/preprocess_mnms.py to:

• split the original 4D data to 3D along the time axis;
• crop and resize;
• save to .npy;
• generate the train/test splits (use labeled data for validation);
• generate the labeled/unlabeled splits.

For all the pre-processing, you can comment out the functions corresponding to splits and use our pre-split files.

Finally, you will get a file structure as follow:

.
├── Synapse_data
│   ├── npy
│   │   ├── <id>_image.npy
│   │   ├── <id>_label.npy
│   │   └── ...
│   └── split_txts
│       ├── labeled_0.2.txt
│       ├── unlabeled_0.2.txt
│       ├── train.txt
│       ├── eval.txt
│       ├── test.txt
│       └── ...
├── LA_data
│   └── ...
├── MMWHS_data
│   └── ...
└── MNMS_data
    └── ...

🔥🔥 This codebase allows train, test, and evaluate on all the four settings using one single bash file. 🔥🔥

Run the following commands for training, testing and evaluating.

bash train.sh -c 0 -e diffusion -t <task> -i '' -l 1e-2 -w 10 -n 300 -d true 

Parameters:

-c: use which gpu to train

-e: use which training script, can be diffusion for train_diffusion.py, or diffusion_2d for train_diffusion_2d.py

-t: switch to different tasks:
          For SSL on 5% labeled LA dataset: la_0.05
          For IBSSL on 20% labeled Synapse dataset: synapse_0.2
          For UDA on MMWHS dataset: mmwhs_ct2mr for labeled CT and unlabeled MR, mmwhs_mr2ct in opposite
          For SemiDG on M&Ms dataset, 2% labeled B,C,D -> A setting: mnms_A_0.02; 5% labeled A,B,C -> D setting: mnms_D_0.05

-i: name of current experiment, can be whatever you like

-l: learning rate

-w: weight of unsupervised loss

-n: max epochs

-d: whether to train, if true, training -> testing -> evaluating; if false, testing -> evaluating

🌟🌟 All trained model weights can be downloaded from this link. 🌟🌟

Put the logs directory under the root directory of this repo and set -d False, then you can test and evaluate the models.

If this code is helpful for your study, please cite:

@inproceedings{wang2023towards,
  title={Towards Generic Semi-Supervised Framework for Volumetric Medical Image Segmentation},
  author={Wang, Haonan and Li, Xiaomeng},
  booktitle={Thirty-seventh Conference on Neural Information Processing Systems},
  year={2023}
}

Haonan Wang ([email protected])

This repository is released under MIT License.