xdurana / vor Goto Github PK

Reproducing results of Clopath et al. model of the vestibulo-ocular reflex

1. Clopath, C., Badura, A., De Zeeuw, C. I. & Brunel, N. A cerebellar learning model of vestibulo-ocular reflex adaptation in wild-type and mutant mice. J. Neurosci. 34, 7203–15 (2014).

2. Wulff, P., Schonewille, M., Renzi, M., Viltono, L., Sassoè-Pognetto, M., Badura, A., … De Zeeuw, C. I. (2009). Synaptic inhibition of Purkinje cells mediates consolidation of vestibulo-cerebellar motor learning. Nature Neuroscience, 12(8), 1042–9. http://doi.org/10.1038/nn.2348

This is a phase-reversal VOR adaptation experiment. It consists of 9 sessions: 5 training sessions and 4 light deprivation sessions. Gain 1 is defined as the amplitude at the end of the second session.

1. 50 minutes training session with light and target gain 1
2. 2 sessions of 1440 minutes of light deprivation
3. 50 minutes training session with light and target gain 0
4. 1440 minutes of light deprivation
5. 50 minutes training session with light and target gain -0.5
6. 1440 minutes of light deprivation
7. 50 minutes training session with light and target gain -1
8. 1440 minutes of light deprivation
9. 50 minutes training session with light and target gain -1

• Clopath detailed model
• Clopath detailed model with NOI, without vestibular decay (H=0) and with alpha_d>0
• Clopath detailed model with NOI, without vestibular decay (H=0) and with alpha_d=0
• Clopath detailed model with NOI, without vestibular decay (H=0) and with alpha_d>0 and with k*(PC-PC_ini)
• Clopath detailed model with NOI, without vestibular decay (H=0) and with alpha_d=0 and with k*(PC-PC_ini)

And with long session of light deprivation:

10. 7*1440 minutes of light deprivation

• Clopath detailed model
• Clopath detailed model with NOI, without vestibular decay (H=0) and with alpha_d>0
• Clopath detailed model with NOI, without vestibular decay (H=0) and with alpha_d=0
• Clopath detailed model with NOI, without vestibular decay (H=0) and with alpha_d>0 and with k*(PC-PC_ini)
• Clopath detailed model with NOI, without vestibular decay (H=0) and with alpha_d=0 and with k*(PC-PC_ini)