This repository contains codes and processed files for the manuscript entitled "An integrative TAD catalog in lymphoblastoid cell lines discloses the functional impact of deletions and insertions in human genomes.". Specifically, it includes the code scripts corresponding to the analyses of the main results listed below:

1. TAD boundary calling by Insulation Score
2. Comprehensive TAD catalog integration
3. Quantification of SVs’ impact on 3D chromatin structure, gene expression, and splicing levels
4. Replication of SVs’ impact on 3D chromatin structure