Giter Club home page Giter Club logo

methypre's Introduction

methyPre

Methylation array preprocessing.

This package is downloadable using the following in R:
require(devtools); install_github("metamaden/methyPre")

Purpose

This package contains a single wrapper function that serves as an all-in-one workflow assembly. It takes an experiment summary object as used in minfi (eg. RGChannelSet, MethylSet, GenomicRatioSet, etc.) and applies minfi normalizations, filters, and batch correction. The workflow decision tree, including all arguments and operations, is as follows:

alt text

Citations

For more info, see the minfi Bioconductor page. For information on cross-reactive and poor quality probes, see Chen et al 2013 (HM450 platform), and Pidsley et al 2016 (EPIC platform).

NEWS/TODO

1/20/18

Improvements planned: consider contingencies or exceptions and add more messages. Consider adding an estimate for object size and enabling a user interaction (whether to accept or decline based on available memory, the list objects get huge pretty quickly).

methypre's People

Contributors

metamaden avatar

Stargazers

 avatar  avatar  avatar  avatar  avatar  avatar

Watchers

 avatar  avatar

Forkers

gradylab

methypre's Issues

there might be an error during filtering the undetected CpGs

Hi Sean, I found that preObj2 and detP had different orders of CpGs (rownames), maybe because the upstream normalization steps changed the CpG order (It would be good if you can double check this), therefore, the Line 50 of methyPre.R filtering by a TRUE/FALSE vector "failed" may not be correct. I suggest preObj3 <- preObj2[setdiff(rownames(preObj2), rownames(detP)[failed]),]. Please let me know if you update the package. Thanks!

Recommend Projects

  • React photo React

    A declarative, efficient, and flexible JavaScript library for building user interfaces.

  • Vue.js photo Vue.js

    ๐Ÿ–– Vue.js is a progressive, incrementally-adoptable JavaScript framework for building UI on the web.

  • Typescript photo Typescript

    TypeScript is a superset of JavaScript that compiles to clean JavaScript output.

  • TensorFlow photo TensorFlow

    An Open Source Machine Learning Framework for Everyone

  • Django photo Django

    The Web framework for perfectionists with deadlines.

  • D3 photo D3

    Bring data to life with SVG, Canvas and HTML. ๐Ÿ“Š๐Ÿ“ˆ๐ŸŽ‰

Recommend Topics

  • javascript

    JavaScript (JS) is a lightweight interpreted programming language with first-class functions.

  • web

    Some thing interesting about web. New door for the world.

  • server

    A server is a program made to process requests and deliver data to clients.

  • Machine learning

    Machine learning is a way of modeling and interpreting data that allows a piece of software to respond intelligently.

  • Game

    Some thing interesting about game, make everyone happy.

Recommend Org

  • Facebook photo Facebook

    We are working to build community through open source technology. NB: members must have two-factor auth.

  • Microsoft photo Microsoft

    Open source projects and samples from Microsoft.

  • Google photo Google

    Google โค๏ธ Open Source for everyone.

  • D3 photo D3

    Data-Driven Documents codes.