lifesci-ai-repo's Introduction

Resources for Life Science Data Science

Repository of all life science resources (readings, datasets etc.), codebases and dashboards

Selected Scientific Literature

Are drug targets with genetic support twice as likely to be approved? Revised estimates of the impact of genetic support for drug mechanisms on the probability of drug approval: Quantifies the impact of genetic evidence on a drug's probability of being approved. Must read for those building at the intersection of biopharma and tech
Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs: Google's deep learning study on diabetic retinopathy. Big money buys big datasets, but a classic work that set the gold standard in the field of DL for medicine
Clinically applicable deep learning for diagnosis and referral in retinal disease: Another high profile study by Google on opthalmology imaging. Sequel to above paper but with much greater implication for clinical practice.

Dataset Name	Data Modalities	Link
UK BioBank	Genomics (Whole Exome Seq.), Imaging (Radiology, Ophthalmology etc.), Clinical Phenotypes (ICD, nurse diagnosis etc.)	https://www.ukbiobank.ac.uk
The Cancer Genome Atlas (TCGA)	Genomics (Whole Genome Seq., RNA-Seq, Methylation array etc.), Whole Slide Images, Radiology (TCIA, limited), Structured Clinical Data (only outcome available is OS)	https://portal.gdc.cancer.gov
The Cancer Imaging Archive	Imaging, Clinical, limited Genomics (some overlap with TCGA)	https://www.cancerimagingarchive.net
Clinical Proteomic Tumor Analysis Consortium (CPTAC)	Proteomics, Genomics, Imaging, limited Clinical	https://cptac-data-portal.georgetown.edu/cptacPublic/
MIMIC III Dataset	Structured Clinical Data (prescription, ICD diagnosis, lab values) and unstructured (clinical notes, images, ECG etc.)	https://mimic.physionet.org/

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