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idr_stream's Introduction

Hi there! Welcome to my profile ๐Ÿค—

I am a young computational biologist ๐Ÿ‘ฉ๐Ÿปโ€๐Ÿ’ป, just trying to find her place in the world ๐ŸŒŽ

  • ๐Ÿ”ญ Iโ€™m currently working on multiple image-based analysis projects in the Gregory P. Way lab.
  • ๐ŸŒฑ Iโ€™m currently learning how to grow my knowledge of Python and R. One of my biggest goals is to improve my biostatistics and machine learning skills.

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My current projects

If you are curious about the projects I am working on, here is a list of the repositories:

  1. NF1 Cell Painting Project - Image analysis and image-based profiling of Schwann cells of different genotypes (WT, Null, and HET) to identify a biomarker.
  2. CFReT Project - Image analysis, image-based profiling, and machine learning to predict healthy or failing cell types of cardiac fibroblasts.
  3. Pyroptosis Signature Project - Image analysis and image-based profiling of PBMCs and SHSY-5Ys to use in cell death prediction.

Publications

We submitted a preprint for our project titled "Toward generalizable phenotype prediction from single-cell morphology representations". This paper describes our work to make a generalizable model predicting phenotype based on nucleus features utilizing the Mitocheck 2015 labeled dataset. We applied this model to the JUMP consortium and performed a Leave One Image Out analysis, discovering that many features are variable across datasets, leading to problems with generalizability. We propose different steps to solving this issue within our discussion.

idr_stream's People

Contributors

jenna-tomkinson avatar roshankern avatar

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