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tcrdb's Introduction

TCRdb: A comprehensive database of T-cell receptor sequences in various conditions

TCRdb contains more than 277 million highly reliable TCR sequences from over 8265 TCR-Seq samples across hundreds of tissues/clinical conditions/cell types. The unique features of TCRdb include:

  • Comprehensive and reliable sequences for TCR repertoire in different samples generated by a strict and uniform pipeline of TCRdb;
  • Powerful search function, allowing users to identify their interested TCR sequences in different conditions;
  • Categorized sample metadata, enabling comparison of TCRs in different sample types;
  • Interactive data visualization charts, describing the TCR repertoire in TCR diversity, length distribution and V-J gene utilization.

The TCRdb database is freely available at http://bioinfo.life.hust.edu.cn/TCRdb/

Description

CATT .smk, MiXCR.smk, IMSEQ.smk: The parameters used for each method.

Download.smk: For data download from NCBI.

QC_single/double.smk: For raw data quanlity control.

All the pipepines were written in Snakemake.

Citing

Si-Yi Chen, Tao Yue, Qian Lei, An-Yuan Guo, TCRdb: a comprehensive database for T-cell receptor sequences with powerful search function, Nucleic Acids Research, , gkaa796, https://doi.org/10.1093/nar/gkaa796

tcrdb's People

Contributors

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Forkers

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tcrdb's Issues

Download data of immunoSEQ projects

Thanks for building such a great database! I noticed that in the download section, only PRJ* projects are available. I'm trying to download the data of the immunoSEQ projects, but the only way I know to do it's to go to each sample and download sample data one by one. Is there an efficient method to download the entire project data? Thank you in advance!

Website is not reachable

Hi,
For a research project we would like to use TCRdb but unfortunately encountered the issue, that the website is not available. Is there another way to access and download the data, or will the website be available soon? Thanks in advance.

Total CDR3 sequences of TCRdb

TCRdb is a very powerful CDR3 database, with nearly 300 million CDR3 sequences. For the purpose of research, we need the data set for machine learning training, so we counted the data amount of this data(POST and crawl ), but found that there are only over 40 million data in the database, which is a little weird,is there still data not published?thanks

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