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Cliniface lets clinicians interactively visualise, measure, analyse, and export data and reports about 3D facial images taken of their patients. Cliniface records a comprehensive range of facial measurements and compares these against known statistics of facial growth to automatically identify significant dysmorphic traits as standard Human Phenotype Ontology (HPO) terms which have disease/gene associations. By combining the HPO terms reported by Cliniface with other phenotypic information (including medical/family histories etc), a clinician is better able to quickly and accurately arrive at a potential diagnosis. Cliniface can then summarise the analysis in a PDF report, or export the analysis to CSV (or other text formats) for detailed follow-up investigations if required.

Cliniface takes over fifty measurements from different parts of the face including distances, depth, angles, and asymmetry. In addition, Cliniface offers clinicians the ability to record their own measurements on the 3D facial image in an intuitive and easy manner using "virtual callipers". Visualisations of asymmetry and curvature are also provided to help clinicians more effectively interpret the facial surface.

Cliniface works with 3D facial models stored in a wide variety of formats including formats without texture information. The protection and privacy of subject information is ensured because all processing is carried out on your own machine.

Cliniface is free and open source. If you find Cliniface useful and would like to help us to improve it, or you'd like to use it to help in your own research, please contact us for further details.

Cliniface is free software: you can redistribute it and/or modify it under the terms of the GNU General Public License as published by the Free Software Foundation, either version 3 of the License, or (at your option) any later version. Cliniface is distributed in the hope that it will be useful, but WITHOUT ANY WARRANTY; without even the implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.
See the GNU General Public License for more details.

You should have received a copy of the GNU General Public License along with this program.
If not, see http://www.gnu.org/licenses/.

Cliniface's development is supported mainly through research grants and from contributions by partner organisations. The following organisations have helped in Cliniface's development:

• Angela Wright Bennet Foundation
• Borlaug Foundation
• Curtin University
• FASD Research Australia Centre for Research Excellence
• FrontierSI (formerly Cooperative Research Centre for Spatial Information)
• Genetic Services of Western Australia
• Genome.One
• Linear Clinical Research
• McCusker Charitable Foundation
• Murdoch Children's Research Institute
• Patches Paediatric Clinics
• Perth Children's Hospital Foundation
• RD-Connect
• Roy Hill Community Foundation
• Sanofi
• Telethon Kids Institute, Genetic and Rare Diseases Program
• The Western Australian Register of Developmental Anomalies
• The Western Australian Department of Health

Special thanks to the rest of the Cliniface team, past and present including: Petra Helmholz, Paula Fievez, Lyn Schofield, Dylan Gration, Cathryn Poulton, Yarlalu Thomas, Stefanie Kung, Tracey Tsang, and Hedwig Verhoef. Very special thanks to clinical geneticist Gareth Baynam whose vision, passion, and humility is key to Cliniface's ongoing success.

If you use Cliniface in your research, please cite the following work:
Palmer, R. L., Helmholz, P., and Baynam, G.: CLINIFACE: PHENOTYPIC VISUALISATION AND ANALYSIS USING NON-RIGID REGISTRATION OF 3D FACIAL IMAGES, Int. Arch. Photogramm. Remote Sens. Spatial Inf. Sci., XLIII-B2-2020, 301-308, https://doi.org/10.5194/isprs-archives-XLIII-B2-2020-301-2020, 2020.

Cliniface uses a custom implementation of a third-party non-rigid registration algorithm and includes a copy of the anthropometric mask created by that algorithm's authors (supplied with permission), so please cite the following works (follow the links for full citation details):
https://doi.org/10.1038/s41598-019-42533-y
https://doi.org/10.1371/journal.pone.0207895

Cliniface is free and open source software. It depends upon the efforts of the many researchers, developers, and maintainers of the following open source software products and technologies. We salute your benevolence.

• rlib (https://github.com/richeytastic/rlib)
• rimg (https://github.com/richeytastic/rimg)
• r3d (https://github.com/richeytastic/r3d)
• r3dio (https://github.com/richeytastic/r3dio)
• r3dvis (https://github.com/richeytastic/r3dvis)
• rNonRigid (https://github.com/richeytastic/rNonRigid)
• QTools (https://github.com/richeytastic/QTools)
• nanoflann (https://github.com/jlblancoc/nanoflann)
• IDTF to U3D converter (http://www2.iaas.msu.ru/tmp/u3d)
• Open Asset Import Library (http://assimp.sourceforge.net)
• libbuild (https://github.com/richeytastic/libbuild)
• QuaZip (https://github.com/stachenov/quazip)
• Sol2 (https://github.com/ThePhD/sol2)
• MiKTeX (https://miktex.org/portable)
• Eigen3 (http://eigen.tuxfamily.org)
• Boost (http://www.boost.org)
• OpenCV (https://opencv.org)
• Icons8 (https://icons8.com)
• VTK (https://www.vtk.org)
• Lua (http://www.lua.org)
• Qt (https://www.qt.io)