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Eric L. Denovellis

About me

I am a computational research scientist in Dr. Loren Frank's lab at UCSF. My work focuses on developing scalable, interpretable algorithms and tools to decode, categorize and visualize neural representations. This work extends and applies marked point process switching state space models I developed during my postdoc with Dr. Uri T. Eden. I work closely with experimental collaborators to ensure these algorithms and tools are usable on large scale data.

I also build open source software packages for neural data analysis. These include:

  • replay_trajectory_classification a Python package for decoding spatial position represented by neural activity and categorizing the type of trajectory.
  • Spyglass is a data analysis framework that facilitates the storage, analysis, visualization, and sharing of neuroscience data to support reproducible research. It is designed to be interoperable with the NWB format (a data standard for neurophysiology) and integrates open-source tools such as SpikeInterface and DeepLabCut into a coherent framework.
  • spectral_connectivity is a Python software package that computes multitaper spectral estimates and frequency-domain brain connectivity measures such as coherence, spectral granger causality, and the phase lag index using the multitaper Fourier transform.

Previously, I completed my PhD in computational neuroscience at Boston University with Drs. Daniel H. Bullock and Earl K. Miller. There I developed computational tools and models to understand how prefrontal cortex supports the underlying neural comptuations necessary to switch between contexts. Specifically:

  • I showed how synchronous network oscillations in the prefrontal cortex provide a mechanism to flexibly coordinate context representations between groups of neurons during task switching
  • I used generalized additive models to show that anterior cingulate neurons can represent context, but do not play a significant role in switching between contexts
  • Finally, I developed a set of web-enabled interactive visualization tools designed to provide a multi-dimensional integrated view of electrophysiological datasets.

Contact Me: Email

Eric Denovellis's Projects

atom icon atom

:atom: The hackable text editor

better-science-code icon better-science-code

A presentation on best coding/data management practices based on my own experiences of scientific computing and data analysis and heavily borrowing from the recommendations of many others. View presentation at: https://edeno.github.io/Better-Science-Code

clearmap2 icon clearmap2

ClearMap 2.0 with WobblyStitcher, TubeMap and CellMap

cloudtogrid icon cloudtogrid

Example of converting a 2d point cloud to a 2d grid via the assignment problem.

conda-auto-env icon conda-auto-env

Automatically activate a conda environment when entering a folder with an environment.yml file

d3-save-svg icon d3-save-svg

Extracts an SVG node and accompanying styles from an HTML document and allows you to download it all as an SVG file.

deeplabcut icon deeplabcut

Markerless tracking of user-defined features with deep learning

hdmf icon hdmf

The Hierarchical Data Modeling Framework

hungarian icon hungarian

Hungarian / Munkres' algorithm for the linear assignment problem, in Python

iohmm icon iohmm

Input Output Hidden Markov Model (IOHMM) in Python

jax icon jax

Composable transformations of Python+NumPy programs: differentiate, vectorize, JIT to GPU/TPU, and more

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