This Project reports my summer research on the effect of dexamethasone (a corticosteroid used in cancer treatment) on the effectiveness of cis-platin (a popular chemotheraphy drug) on patients with Head and Neck Cancer(HNSCC).

Research Purpose:

1. To investigate whether NR3C1 activation by dexamethasone increases resistance to chemotherapy
2. To train a neural network (CNN) to segregate between high NR3C1 gene expression from low using the Xception architecture for informing chemotherapy optimization.

Result: I observed a statistically significant difference between the effectiveness of cis-platin on patients who were treated with dexamethasone prior to administering chemotherapy versus those who were not (with a p-value of 0.015). In particular, dexamethasone appears to counteract cis-platin in HNSCC.

Notice: The data used for patients in clinical trials is not declosed for confidentiality purposes.