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asntech avatar asntech commented on June 15, 2024

That is a lot of BED files! The memory issue is familiar with bedtools/pybedtools using large datasets. Can you use the latest versions of bedtools and pybedtools? Also, try to sort your bed files using bedtools before running the intervene upset.

We're aiming for a parallel processing option in the upcoming version of Intervene!

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alistairhockey avatar alistairhockey commented on June 15, 2024

I haven't had any issues with bedtools multiinter - but maybe the sorting has played a part in that!
Also, have you considered having an option for BEDPE files? I would be interested to see if you could modify the script to use 'pairToPair' in place of 'intersect' to get all the BEDPE paired region combinations.

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