Parameters to vary for simulated data sets about dsc-log-fold-change HOT 2 OPEN

R function poisthin is currently used to generate simulated data.

Location: dsc/modules/dataSimulate.R
Source: Taken from Davis' seqgendiff package
Modifications:

• I added signal_dist argument to specify the desired distribution for the signals, such as "big_normal" and "near_normal" (more can be added later)
• I specified the distribution parameters inside the pois_thin function

Comments:

• We can include this in a separate R package as the function grows

from dsc-log-fold-change.

Another resource is David's seqgendiff package:

This package is designed to take real RNA-seq data and alter it by adding signal to a known proportion of the genes. The advantage of this way of simulating data is that you can see how your method behaves when the simulated data exhibit common (and annoying) features of real data.

from dsc-log-fold-change.