Comments (1)
Some things to consider when building the graphing module @kaozkai and @snaketron:
We have to really think how to structure the resulting graph:
- what is the interpretation of a vertex: a CDR3 sequence or a cell? if v=1 or v=2, then each vertex is a CDR3 sequence; else, each vertex is a cell
- imagine the example from the vignette in which you introduce clonal expansion, i.e. we have 15 cells with the same CDR3 sequences. If we represent each cell as a vertex, then we have a completely connected subgraph of n=15, and the number of edges grows exponentially with n. Maybe we need to think about a special way of representing clonal expansions in the graph.
- edges can represent a) enriched motifs or b) global pairs from CDR3b or CDR3a. Do we show 1 edge in which we somehow encode this information such that it may be retrieved later on, or do we draw multiple edges or a weighted edge?
- maybe there are other points I have missed here ...
We can talk about these points on Thursday.
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Related Issues (20)
- Add additional features
- Check gliphR 1 algorithm
- unit tests
- man files (e.g. using roxygen)
- small examples at the end of man files
- package vignette
- additional vignette about version comparison
- React to user feedback
- Rewrite package description
- Rewrite README.md
- Find gliph3 difference supporting dataset for vignette HOT 1
- Integrate trim warning HOT 1
- Finish vignette
- Version comparison vignette
- check cdr3a / cdr3b plotting
- NAMESPACE file HOT 2
- graph.R and plot_graph.Rd
- directed graph? HOT 1
- compare controls func.
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