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mattodd avatar mattodd commented on July 20, 2024

This is to some extent on hold given the binary SAR of the previous round of evaluation.
(URI: http://malaria.ourexperiment.org/uri/374)

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alintheopen avatar alintheopen commented on July 20, 2024

I think we should definitely buy it if we need anymore. We currently have g(s) and it depends which molecules we focus on following the consultation.

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nicolaswlo avatar nicolaswlo commented on July 20, 2024

Have you already try to N-alkylate the pyrimidone MNR89-2? That should improve the solubility. It's also commercially available.

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murrayfold avatar murrayfold commented on July 20, 2024

We've got 20 g of AT-1-3 (commercial) and about 3 g of MNR89-2 (synthesised as above). Maybe based on the new cores that we might be looking at we put this request on hold for now?

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