TypeError in expression_profile.py about driven HOT 4 OPEN

from cobra.core.gene import parse_gpr
from sympy import Mul, Add, Symbol, Max, Min
from ast import And, Or, NodeTransformer

class Transform(NodeTransformer):

    def visit_Name(self, node):
        return Symbol(node.id)
    def visit_BoolOp(self, node):
        values = [self.visit(v) for v in node.values]
        if isinstance(node.op, And):
            return Mul(*values)
        if isinstance(node.op, Or):
            return Add(*values)
        return node

def parse_expr(s):
    a, genes = parse_gpr(s.strip())
    a = Transform().visit(a)
    return a.body

def _map_gene_to_rxn(self, reaction, gene_values, by):
    rule = reaction.gene_reaction_rule
    expression = parse_expr(rule)
    if by == "or2max_and2min":
        expression = expression.replace(Mul, Min).replace(Add, Max)
    elif by == "or2sum_and2min":
        expression = expression.replace(Mul, Min)
    return expression.subs(gene_values).evalf()

from driven.data_sets.expression_profile import ExpressionProfile
ExpressionProfile._map_gene_to_rxn = _map_gene_to_rxn