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2010   Ph.D.   Botstein Lab, Princeton University 2004   B.S.     Massachusetts Institute of Technology Faculty Profile   |   ORCID   |   Allen Distinguished Investigator   |   Bio

My laboratory aims to understand the rules governing emergent systems-level behavior and to use these rules to rationally engineer biological systems. We make quantitative measurements, often at the single-cell level, to test different conceptual frameworks and discriminate among different classes of models. Areas of focus include:

• Translational control of protein synthesis: Mechanisms by which ribosomal modifications regulate protein synthesis
• Single-cell protein analysis: We develop and apply mass-spectrometry methods that allow analyzing thousands of proteins in single cells. These data have enabled characterizing post-transcriptional regulation in single cells at systems level, as well as discovering macrophage polarization in the absence of polarizing cytokines.

• Selected research articles
• Publication on PubMed
• Publication on Google Scholar
• Personal blog

I received a BS from MIT in 2004 and then pursued doctoral research in the Botstein laboratory at Princeton University, aiming to understand how cells coordinate their growth, gene expression, and metabolism. As a postdoc in the van Oudenaarden laboratory at MIT, I characterized trade-offs of aerobic glycolysis (also known as Warburg effect) and obtained direct evidence for differential stoichiometry among core ribosomal proteins, suggesting that specialized ribosomes regulate protein synthesis.