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biofuture avatar biofuture commented on August 17, 2024

For many of the currently generated biological data, they are all with this feature, such as metabolomics, cytokines data. The machine has a detection limit for the concentration if your tool can support this type of imputation, I think many people would like to use your tool in their study.

Best wishes!

from gain.

jsyoon0823 avatar jsyoon0823 commented on August 17, 2024

Unfortunately, I do not think GAIN (and other data-driven methods) can be used for this setting.
It is very hard for data-driven methods to estimate something out of the distribution from the observed data.
I suggest that instead of using the imputation, it may be good to use the missingness as the additional feature (binary feature) and put the missing parts as 0.

from gain.

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