Error with cleft.threshold in fanc_partner_summary about fancr HOT 6 OPEN

The issue seems to be the that there is no cleft score for FANC synapse data. You can filter synapses by score though. What would a good threshold be?

I have started to implement this in two branches, for fafbseg and for fancr.

If anyone else wants to finish implementing great - I ran out of time today, but will try to over weekend.

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Thanks @yanghelenh. As Alex says there is no cleft.threshold information available for FANC. You could talk to @unidesigner about this. I left the implementation (which is inherited from FAFB) in the hope that it might one day be available.

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@alexanderbates thanks for the work you mention re the plain connection_score. Unfortunately I have no indication that it does anything useful. For example I've looked there is no correlation between connection_score and cleft_score, but I know that high cleft_scores are predictive of true synapses. For example here are the input synapses onto a sample neuron (720575940621039145) plotted.

If I plot synapses above (green) and below (red) a cleft_score of 50 then you can clearly see a preponderance of red synapses in obviously incorrect places (eg the soma and axon shaft).

But I cannot find a connection_score that separates e.g. false synapses on the axon shaft from the arbours. You have generated a validated dataset with Imaan curating FAFB synapses so if you want to see if there is anything about connection_score that is predictive, I would be happy to hear it.

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PS score in flywire_partners() = connection_score as returned by CAVE.

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Thanks @jefferis and @alexanderbates for looking into this issue for me. It was clear from the error that cleft.threshold wasn't returning anything, but I didn't realize that it's because this information isn't available for FANC. I'll talk to @unidesigner about whether it could be implemented for FANC, or if there's some other way to filter the predicted synapses by confidence.

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Hm... using the flywire_cave_query function of fafbseg to get a FANC neuron's output synapses returns a column called score, but unlike the connection_score, the values seem to range between 13 and 150ish with a mean around 30ish. It seems like the score for FANC predicted synapses might be its own thing.

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