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anle138b

Therapeutic trial of anle138b in mouse models of genetic prion disease

aso_in_vitro

Characterization of the prion protein binding properties of antisense oligonucleotides

aso_survival

Antisense oligonucleotides extend survival of prion-infected mice

binder_screening

Screening for small-molecule PrP binders

callability

Comparison of callability in whole genomes vs. whole exoms

cheminformatics_tools

Miscellaneous scripts useful for chemical informatics

citedown

Code for making Markdown-compatible citations

cns_prp_quant

PrP concentration in the central nervous system

cnsdrugs

List of FDA-approved drugs and CNS drugs with SMILES

cryptic_exon

Modulation of prion protein expression through cryptic splice site manipulation

csf_prp_quantification

Quantification of PrP in CSF as a pharmacodynamic biomarker

cumulus-ac_1c

Cloud-based scalable and efficient single-cell genomics workflows

cureffi

CureFFI.org

diversity-score

Compute diversity scores for all individuals with a variant allele

drug_target_lof

Evaluating potential drug targets through human loss-of-function genetic variation

e200k-anticipation

Simulations and analyses of ascertainment bias in E200K genetic prion disease

exac_hgmd

HGMD mutations in ExAC exomes

exome-qc

Generate QC stats on individual exomes

familinx

A few quick analyses using Yaniv Erlich's FamiLinx dataset

fibonacci

Example repo for a git tutorial

fragments

NMR fragment screening

genetic_support

Refining the impact of genetic evidence on clinical success

genetics_side_effects

Human genetic evidence enriches for side effects of approved drugs

genetics_tools

Stuff for the wet lab. Scripts for designing CRISPR guide RNAs, primers and so on.

gpi

Analysis of GPI-anchored proteins

gtexqc

Comparison of coverage and genotypes in multiple datasets for GTEx

hd-rnaseq

Analyses of various RNA-seq datasets related to Huntington's disease

hydrocephalus

Analysis of hydrocephalus reports in nusinersen

ko_snps

B9 vs. 129 SNPs in different lines of PrP knockout mice

loftee