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pratikunterwegs avatar pratikunterwegs commented on June 12, 2024

The current model structure is chosen with reference to empirical findings from the Covid-19 pandemic, that vaccinated individuals are less likely to be infected, and less likely to suffer adverse outcomes from infection (hospitalisation and death).

This model structure could be simplified in two different ways:

  1. Two-dose vaccination only reduces the rate at which individuals are infected ($\beta$ by a factor), but has no effect on further infection compartment transitions;
  2. Two-dose vaccination reduces all transition rates by a uniform factor;
  3. Removing the H, ICU, and D compartments which may not add much information and which could be estimated separately from known conversion rates. The H compartment might become important for outbreaks where hospitalisation also indicates quarantine, as these individuals are no longer available to infect others.

Conversely the model could be made more complex to reflect that:

  1. Some vaccinated individuals might never become infectious, and transition directly to the recovered compartment;
  2. The mortality rate increases when individuals enter more serious healthcare compartments (e.g. ICU > H > I).

from epidemics.

pratikunterwegs avatar pratikunterwegs commented on June 12, 2024

Hi @bahadzie I'm just reopening this issue - the idea with the "Discussion" issues is that they remain open even when they're marked as done.

from epidemics.

bahadzie avatar bahadzie commented on June 12, 2024

Apologies @pratikunterwegs I thought I clicked on the dropdown arrow next to the 'Close with comment' button to see what other options were available.

from epidemics.

pratikunterwegs avatar pratikunterwegs commented on June 12, 2024

Closing as this model is stable.

from epidemics.

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