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abm_pde_phenotypes

physimess

PhysiCell MicroEnvironment Structure Simulation

summervacationproject2022

In this project we will use a previously developed c++ 3D off-lattice agent-based multi-scale model which simulates the behaviour of, and spatio-temporal interactions between various tumour agents (namely cells and blood vessels) to investigate how tumour growth patterns and inherent spatial heterogeneity are driven by oxygen phenotypes of cells. Within the existing model mechanical interactions between agents occur through repulsion and adhesive forces and these are coupled to a finite element solver which solves a reaction-diffusion equation for chemical substances (e.g. oxygen) which diffuse throughout the 3D tissue domain from sources (e.g. blood vessels) and are consumed by agents (e.g. cells). Agent behaviour is governed both by the mechanical interactions and changes to their phenotype. In this project we will allow cells to sample across a discrete range of phenotypes representing a continuum between normoxic and hypoxic behaviour in order to investigate how cell phenotype is structured by the local environment and how in turn cell phenotype affects patterns of tumour growth. Thus allowing us to better understand the specific mechanisms that occur in the tumour microenvironment and underpin tumour development. This project seeks to apply an agent-based approach to compare to an earlier continuous PDE formalism of phenotypic heterogeneity in vascularised tumours.

virtualtumour

3d agent-based, multiscale tumour and tumour microenvironment model

ws2022

2022 PhysiCell Hackathon and Workshop